faculty

Wipawee "Joy" Winuthayanon

Wipawee "Joy" Winuthayanon

Assistant Professor

winuthayanonw@vetmed.wsu.edu

Office
Room: BLS 239
Phone: 509-335-8296

Lab
Room: BLS240
Phone: 509-335-8671

Lab Website

 

Research and Interests

Approximately 50-80 million reproductive age couples worldwide suffer from infertility. These couples encounter psychological distress, including low self-esteem, isolation, and depression; emphasizing the need for a better understanding the causes of infertility. At Winuthayanon Lab, we focus on studying how ovarian steroid hormones (estrogen and progesterone) affect fertility during sperm and embryo transport within the female reproductive tract. There are multiple components of the cells in female reproductive tract that work in concert to provide optimal microenvironment for gametes (eggs and sperm) and the embryos to establish successful pregnancy. In our lab, we use genetic engineered mouse models to dissect the molecular mechanisms and functional requirement of estrogen and estrogen signals during pregnancy. Our research aims to provide basic knowledge in reproductive biology during early pregnancy as well as potential targets for contraceptive agents and therapeutic approaches for infertility.

Winuthayanon infographic
Publications on PubMed

Select Publications

  • Hewitt SC, Winuthayanon W, Korach KS (2016) What’s new in estrogen receptor action in the female reproductive tract. J Mol Endocrin. 56, R55-71 PMID: 26826253 PMCID: PMC4733493
  • Winuthayanon W, Bernhardt ML, Padilla-Banks E, Myers PH, Edin ML, Lih F, Korach KS, Williams CJ (2015) Oviductal estrogen receptor α signaling prevents protease-mediated embryo death eLIFE 4 PMID: 26623518 PMCID: PMC4718728
  • Binder AK, Winuthayanon W, Hewitt SC, Couse JF, Korach, KS (2015) Steroid Receptors in the Ovary and Uterus. Plant TM and Zeleznik AJ (eds.), Knobil and Neill’s Physiology of Reproduction 1
  • Hewitt SC, Winuthayanon W, Pockette B, Kerns RT, Suksamrarn A, Piyachaturawat P, Bushel PR, Korach KS (2015) Development of phenotypic and transcriptional biomarkers to establish activity and potency of candidate xenoextrogens. Environ Health Perspect. 123, 334-52
  • Winuthayanon W, Hewitt SC, Korach KS (2014) Uterine epithelial cell Estrogen Receptor α –dependent and –independent genomic profiles that underlie estrogen response. Biol Reprod. 95, 110, 1-10
  • Hewitt SC, Li L, Grimm SA, Winuthayanon W, Hamilton KJ, Pockette B, Rubel CA, Pedersen LC, Fargo D, Lanz RB, DeMayo FJ, Schütz G, Korach KS (2014) Novel DNA Motif Binding Activity Observed in vivo with an ERα Mutant Mouse. Mol Endo. 28, 899-911 PMID: 24713037 PMCID: PMC4042070
  • Winuthayanon W, Piyachaturawat P, Suksamrarn A, Burns KA, Arao Y, Hewitt SC, Pedersen LC, Korach KS (2013) The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor α. Environ Health Perspect. 121(4), 433-9 PMID: 23552522 PMCID: PMC3620745
  • Winuthayanon W, Hewitt SC, Orvis GD, Behringer RR, Korach KS (2010) Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses Proc Natl Acad Sci U S A. 107(45), 19272-7 PMID: 20974921 PMCID: PMC2984169
  • Winuthayanon W, Piyachaturawat P, Suksamrarn A, Ponglikitmongkol M, Arao Y, Hewitt SC, Korach KS (2009) Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms.      Environ Health Perspect. 117, 1155-61 PMID: 19654927 PMCID: PMC2717144
  • Winuthayanon W, Suksen K, Boonchird C, Chuncharunee A, Ponglikitmongkol M, Suksamrarn A, Piyachaturawat P (2009) Estrogenic activity of diarylheptanoids from Curcuma comosa Roxb. requires metabolic activation. J Agric Food Chem. 57(3), 840-5 PMID: 19143535
  • Deroo BJ, Burns KA, Winuthayanon W, Korach KS (2009) Potential effects for environmental xeno-oestrogens: Pollution and fertility. The Biochemist. 31, 22-6