faculty
Pat Hunt

Pat Hunt

Professor

pathunt@vetmed.wsu.edu

Office
Room: BLS 333
Phone: 509-335-4954

Lab
Phone: 509-335-4933

 

Research & Interests

Research in the Hunt laboratory focuses on mammalian germ cells, with a major emphasis on meiosis, the specialized cell division that gives rise to the haploid germ cells. In the human female the incidence of pregnancy loss due to chromosome abnormalities is extraordinarily high. This is a reflection of the fact that the meiotic process is highly error-prone and the incidence of errors in women is strongly influenced by age. Thus, a major research focus is on understanding the control of the normal meiotic process in the mammalian female, the mechanisms(s) by which errors occur, and the way in which age influences female meiosis. In addition, a serendipitous finding that resulted from an accidental exposure in our animal facility, has led to a new avenue of research for the Hunt laboratory. The inadvertent exposure of our mice to the estrogen mimic, bisphenol A (BPA) from damaged caging materials (polycarbonate cages and water bottles) led to the realization that environmentally relevant doses of BPA cause meiotic disruption and aneuploidy in the mouse. Current studies focus on determining the reproductive effects of exposure to chemicals with estrogenic activity during different developmental time points.

Publications on PubMed

Select Publications

  • Sartain C, Hunt PA () An old culprit but a new story: BPA and ‘NextGen” bisphenols Fertility and Sterility
  • Hunt PA, Sathyanarayana S, Fowler PA, Trasande L (2016) Female Reproductive Disorders, Diseases and Costs of Exposure to Endocrine Disrupting Chemicals in the European Union. J Clin Endocrinol Metab. 101(4), 1562-70 PMID: 27003299 PMCID: PMC4880176
  • Gerona RR, Pan J, Zota AR, Schwartz JM, Friesen M, Taylor JA, Hunt PA, Woodruff TJ (2016) Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Environ Health. 15, 50 PMID: 27071747 PMCID: PMC4828888
  • Gruhn J, Al-Asmar N, Fasnacht R, Maylor-Hagen H, Peinado V, Rubio C, Broman K, Hunt P, Hassold T (2016) Correlations between synaptic initiation and meiotic recombination: A study of humans and mice. Am J Hum Genet 98, 102-115
  • Yang QE, Nagaoka SI, Gwost I, Hunt PA, Oatley JM (2015) Inactivation of Retinoblastoma Protein (Rb1) in the Oocyte: Evidence That Dysregulated Follicle Growth Drives Ovarian Teratoma Formation in Mice. PLoS Genet. 11(7) PMID: 26176933 PMCID: PMC4503754
  • Vrooman L, Oatley J, Griswold J, Hassold T, Hunt P (2015) Estrogenic exposure alters the spermatogonial stem cells in the developing testis, permanently reducing crossover levels in the adult. PLoS Genet 11
  • Melin VE, Potineni H, Hunt P, Griswold J, Siems B, Werre SR, Hrubec TC (2014) Exposure to common quaternary ammonium disinfectants decreases fertility in mice Reprod Toxicol. 50, 163-70
  • Hunt PA, VandeVoort C, Woodruff T, Gerona R (2014) Invalid controls undermine conclusions of FDA studies Toxicol Sci. PMID: 24893712 PMCID: PMC4833096
  • Baier B, Hunt P, Broman K, Hassold T (2014) Variation in genome-wide levels of meiotic recombination is established at the onset of prophase in mammalian males. PLoS Genet. 10
  • Rowsey R, Gruhn J, Broman K, Hunt P, Hassold T (2014) Examining variation in recombination levels in the human female: a test of the production line hypothesis. Am J Hum Genet 95, 108-112
  • Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA (2014) Bisphenol A and reproductive health: Update of experimental and human evidence Environ Health Perspect. 122(8), 775-86 PMID: 24896072 PMCID: PMC4123031
  • Calhoun KC, Padilla-Banks E, Jefferson WN, Liu L, Gerrish KE, Young SL, Wood CE, Hunt PA, Vandevoort CA, Williams CJ (2014) Bisphenol A exposure alters developmental gene expression in the fetal rhesus macaque uterus. PLoS One 9(1) PMID: 24465770 PMCID: PMC3900442
  • Calhoun KC, Padilla-Banks E, Jefferson WN, Liu L, Gerrish KE, Young SL, Wood CE, Hunt PA, Vandevoort CA, Williams CJ (2014) Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via Silastic capsules in pregnancy rhesus monkeys: Relevance for human exposures. PLoS One 9(1) PMID: 24465770 PMCID: PMC3900442
  • Vrooman L, Nagaoka S, Hassold T, Hunt P (2014) Evidence for paternal-age related alterations in meiotic chromosome dynamics in the mouse.      Genetics 196, 385-396
  • Gruhn J, Rubio C, Broman K, Hunt P, Hassold T (2013) Cytological studies of human meiosis: sex-specific differences in recombination originate at, or prior to, establishment of double-strand breaks. PLoS One 8, 85075
  • Gerona RR, Woodruff TJ, Dickenson CA, Pan J, Schwartz JM, Sen S, Friesen MW, Fujimoto VY, Hunt PA (2013) Bisphenol-A (BPA), BPA glucuronide and BPA sulfate in mid-gestation cord serum in a northern California cohort Environ Sci Technol. 47(21), 12477-85 PMID: 23941471 PMCID: PMC3881559
  • Rowsey R, Kashevarova A, Murdoch B, Dickenson C, Woodruff T, Cheng E, Hunt P, Hassold T (2013) Germline mosaicism does not explain the maternal age effect on trisomy. Am J Med Genet 161, 2495-2503
  • Vandenberg LN, Hunt PA, Myers JP, Vom Saal FS (2013) Human exposures to bisphenol A: mismatches between data and assumptions. Rev Environ Health. 28(1), 37-58 PMID: 23612528
  • Murdoch B, Owen N, Stevense M, Smith H, Nagaoka S, Hassold T, McKay M, Xu H, Fu J, Revenkova E, Jessberger R, Hunt P (2013) Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior. PLoS Genet. 9(2) PMID: 23408896 PMCID: PMC3567145
  • Oatley J, Hunt PA (2012) Of mice and (wo)men: purified oogonial stem cells from mouse and human ovaries. Biol Reprod. 86(6), 196 PMID: 22402962
  • Gabriel AS, Hassold TJ (2011) Human aneuploidy: mechanisms and insights into an age old problem. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 19(2), 155-163
  • Hunt PA, Lawson C, Gieske M, Murdoch B, Smith H, Marre A, Hassold T, VandeVoort CA (2012) Bisphenol A alters early oogenesis and follicle formation in the fetal ovary of the rhesus monkey. Can Med Assoc J. 110(2), 236-8 PMID: 20312422 PMCID: PMC1947129