Dr. Terry Hassold
Research & Interests
Over 50% of all human pregnancy loss is due to chromosome imbalance in the fetus, making chromosome abnormalities the leading cause of reproductive failure. One of the primary aims of my laboratory is the use of cytogenetic and molecular techniques to study the origin and etiology of human chromosome abnormalities, with the aim being to uncover basic mechanisms responsible for the errors. Additionally, because of the importance of abnormal meiotic recombination to the genesis of human trisomies, we have recently initiated a series of studies to examine factors responsible for “setting” recombination levels in mammalian males and females.
Gruhn J, Al-Asmar N, Fasnacht R, Maylor-Hagen H, Peinado V, Rubio C, Broman K, Hunt P, Hassold T. Correlations between synaptic initiation and meiotic recombination: A study of humans and mice. Am J Hum Genet 98:102-115, 2016.
Vrooman L, Oatley J, Griswold J, Hassold T, Hunt P. Estrogenic exposure alters the spermatogonial stem cells in the developing testis, permanently reducing crossover levels in the adult. PLoS Genet 11:e1004949.doi:10.1371, 2015.
Rowsey R, Gruhn J, Broman K, Hunt P, Hassold T. Examining variation in recombination levels in the human female: a test of the production line hypothesis. Am J Hum Genet 95: 108-112, 2014.
Vrooman L, Nagaoka S, Hassold T, Hunt P. Evidence for paternal-age related alterations in meiotic chromosome dynamics in the mouse. Genetics 196:385-396, 2014.
Baier B, Hunt P, Broman K, Hassold T. Variation in genome-wide levels of meiotic recombination is established at the onset of prophase in mammalian males. PLoS Genet 10:e1004125, 2014.
Gruhn J, Rubio C, Broman K, Hunt P, Hassold T. Cytological studies of human meiosis: sex-specific differences in recombination originate at, or prior to, establishment of double-strand breaks. PLoS One 8:85075, 2013.
Rowsey R, Kashevarova A, Murdoch B, Dickenson C, Woodruff T, Cheng E, Hunt P, Hassold T. Germline mosaicism does not explain the maternal age effect on trisomy. Am J Med Genet 161:2495-2503, 2013.
Nagaoka S, Hassold T, Hunt P. Human aneuploidy: mechanisms and insights into an age old problem. Nat Rev Genet 13:493-504, 2012.
Gabriel, A. S., T. J. Hassold, et al. (2011). An algorithm for determining the origin of trisomy and the positions of chiasmata from SNP genotype data. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 19(2): 155-163.
Lawson, C., M. Gieske, et al. (2011). Gene expression in the fetal mouse ovary is altered by exposure to low doses of bisphenol A. Biology of reproduction, 84(1): 79-86.
Billings, T., E. E. Sargent, et al. (2010). Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping. PloS one, 5(12): e15340.
Murdoch, B., N. Owen, et al. (2010). Multiple loci contribute to genome-wide recombination levels in male mice. Mammalian genome : official journal of the International Mammalian Genome Society, 21(11-12): 550-555.
Hunt, P. and T. Hassold (2010). Female meiosis: coming unglued with age. Current biology : CB, 20(17): R699-702.
Hassold, T. (2010). ASHG Awards and Addresses. 2009 William Allan Award introduction: Huntington F. Willard. American journal of human genetics, 86(3): 316-317.
Zheng, P., M. D. Griswold, et al. (2010). Predicting meiotic pathways in human fetal oogenesis. Biol Reprod, 82(3): 543-551.
Hassold, T. and P. Hunt (2009). Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew. Current opinion in pediatrics, 21(6): 703-708.
Cheng, E. Y., P. A. Hunt, et al. (2009). Meiotic recombination in human oocytes. PLoS genetics, 5(9): e1000661.
Hunt, P. A., M. Susiarjo, et al. (2009). The bisphenol A experience: a primer for the analysis of environmental effects on mammalian reproduction. Biology of reproduction, 81(5): 807-813.
Hassold, T., T. Hansen, P. Hunt, and C. VandeVoort, Cytological studies of recombination in rhesus males. Cytogenet Genome Res, 2009, 124(2): p. 132-8.
Houmard, B., C. Small, L. Yang, T. Naluai-Cecchini, E. Cheng, T. Hassold, and M.Griswold. Global gene expression in the human fetal testis and ovary. Biol Reprod, 2009., 81(2): p. 438-43.
Myers, J.P., F.S. vom Saal, B.T. Akingbemi, K. Arizono, S. Belcher, T. Colborn, I. Chahoud, D.A. Crain, F. Farabollini, L.J. Guillette, Jr., T. Hassold, S.M. Ho, P.A. Hunt, T. Iguchi, S. Jobling, J. Kanno, H. Laufer, M. Marcus, J.A. McLachlan, A. Nadal, J. Oehlmann, N. Olea, P. Palanza, S. Parmigiani, B.S. Rubin, G. Schoenfelder, C. Sonnenschein, A.M. Soto, C.E. Talsness, J.A. Taylor, L.N. Vandenberg, J.G. Vandenbergh, S. Vogel, C.S. Watson, W.V. Welshons, and R.T. Zoeller. Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A. Environ Health Perspect, 2009., 117(3): p. 309-15.
Muhlhauser, A., M. Susiarjo, C. Rubio, J. Griswold, G. Gorence, T. Hassold, and P.A. Hunt. Bisphenol A effects on the growing mouse oocyte are influenced by diet. Biol Reprod, 2009., 80(5): p. 1066-71.